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The success of Kalydeco, a drug to treat cystic fibrosis, has been decades in the making — since the discovery of the gene associated with the disease. The time from gene discovery to successful drug may be shortening, but there are only a handful of drugs like Kalydeco on the market.

The former Soviet citizens who flooded into Israel two decades ago have changed the country's demographics, helped strengthen the economy and played a significant role in the general rightward shift of the Israeli electorate.

The aircraft is intended to serve the Air Force, the Navy and the Marines for decades to come. But delays and cost overruns keep pushing up the price. Lockheed Martin, the manufacturer, says the cost will come down as production ramps up.

A controversial self-defense statute appears to produce more killings, according to a new study. Advocates for the law say it's working as designed. But researchers have different explanations about what might be happening.

In Silicon Valley and around the world there are thousands of folks toiling away on new technologies, convinced that the thing they are building will transform the way we live. NPR's Steve Henn introduces us to five techies whose research and work he'll be keeping a close eye on in the coming year.

The Magnificent Century, which explores the Ottoman Empire in all its 16th-century glory, is a big hit in Turkey. But the country's prime minister, an Islamist, is angry that the program focuses on palace intrigue involving the sultan and his harem.

NPR's David Greene speaks with some of the cast members of the British TV hit Downton Abbey. The third season premieres in the U.S. Sunday on PBS.

Farmers and ranchers across the country expected to start 2013 with a new farm bill, the legislation setting agricultural policy for the next five years. But the new farm bill got scrapped after more than a year of work when Congress passed the "fiscal cliff" deal.

Michigan's Mackinac Island was fought over by France, England and the United States. The 200-year-old city in northern Lake Huron is a popular tourist destination. But the demolition of old buildings has raised a fierce debate about how to hold onto the past while profiting from it.

By letting the House take up the Senate's fiscal cliff-dodging legislation that raises income tax rates on the wealthiest earners, Speaker John Boehner answered affirmatively a question that had been on many minds: Would he allow an up-or-down floor vote on a bill opposed by most fellow House Republicans?