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In a surprising about-face, Afghan President Hamid Karzai appears to be abandoning his government's long-standing effort to hold peace talks with the Taliban in Pakistan, saying they aren't serious about negotiations. NPR's Quil Lawrence reports.

The Supreme Court returns to the bench this week after its summer recess. The new term begins tomorrow with some 50 cases on the docket, and several of them deal with hot-button political issues. Host Audie Cornish talks with NPR legal affairs correspondent Nina Totenberg about the upcoming Supreme Court term.

On his way out as chairman of the Joint Chiefs of Staff, Adm. Mike Mullen's comments about Pakistan has given public voice to concerns about the country's intelligence agency. Those comments have raised new questions about U.S.-Pakistan relations and what the U.S. should do next.

NPR has named a new president and chief executive officer: Gary Knell, president and CEO of Sesame Workshop, the company that produces Sesame Street.

Gary Knell will take over as CEO and president after a rocky year in which the network lost several top executives and faced renewed funding challenges. He currently leads the company behind Sesame Street and other beloved children's shows.

The constitutional challenge to President Obama's health care overhaul almost certainly will be decided this term. Also making their way to the court are cases involving immigration, affirmative action, gay marriage and the constitutionality of the Defense of Marriage Act. The court starts with a dispute over Medicaid payments.

American Bruce Beutler, Luxembourg-born Jules Hoffman and Canadian-born Ralph Steinman are being honored for their discoveries about the human immune system.

A major march is planned for Wednesday in Manhattan. Meanwhile, similar demonstrations are being held in other cities. And a journalist describes what it was like to be among the 700 arrested on Saturday.

The High Court will take up health care, immigration, affirmative action and other hot-button issues. Meanwhile, Yemen says al-Qaida's top bomb maker wasn't killed in Friday's drone strike.

Both increases were modest, however.